研究について

1: Kawashima Y, Shi L, Fukumoto W, Sun J, Tanaka K, Sakai C, Ishida M, Ishida T, Nakano Y, Loy-Caraos G, Bayasgalan N, Bayarjargal S, Kamimura Y, Aikata H, Yoshinaga S, Chayama K, Awai K, Tashiro S. Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients. J Radiat Res. 2026 Jul 24;67(4):556-567.

2: Sato M, Nakatsuka T, Minami T, Kudo Y, Irie R, Tsujikawa H, Kawaguchi T, Takahashi H, Eguchi Y, Murakami E, Chayama K, Okanoue T, Sakamoto M, Fujishiro M, Koike K, Tateishi R. Machine Learning Approach Enables Highly Accurate Identification of At-Risk Metabolic Dysfunction-Associated Steatohepatitis. Hepatol Res. 2026 May;56(5):753-761.

3: Slović N, Mishra S, Paul S, Oudot MA, Jühling F, Kanzaki H, Moehlin J, Charlot A, Denos M, Durand SC, Katz C, Gadenne C, Felli E, Ono A, Oka S, Higashi T, Nakagawa S, Akuta N, Goossens N, Chayama K, Lupberger J, Crouchet E, Hoshida Y, Baumert TF. Chemoprevention of hepatocellular carcinoma by next-generation antipsychotic aripiprazole. Hepatology. 2026 Mar 13 [Epub ahead of print].

4: Kakisaka K, Nakayama N, Sasaki T, Kumagai K, Kuroda H, Abe R, Takami T, Chayama K, Shimizu M, Genda T, Terai S, Inoue K, Tanaka A, Matsumoto T, Mochida S. Liver Volumetry Enhances Prediction of Acute Pancreatitis in Acute Liver Failure: A Nationwide Registry Study. Hepatol Res. 2026 Feb;56(2):233-245.

5: Naderi M, Kordkatuli K, Makokha GN, Moradi A, Mehravar F, Hijikata M, Chayama K. The Prevalence and Risk Factors of Hepatitis B, Hepatitis C, and Hepatitis D Coinfection in Iran’s General Population Over the Past 25 Years: A Systematic Review and Meta-Analysis. J Epidemiol Glob Health. 2025 Dec 28;16(1):2.

6: Shi Z, Tsuge M, Collier N, Takeuchi Y, Uchida T, Rutter CM, Teraoka Y, Uprichard SL, Ishida Y, Tateno C, Ozik J, Dahari H, Chayama K. Modeling of hepatitis B virus infection spread in primary human hepatocytes. J Virol. 2025 Sep 23;99(9):e0092725.

7: Gad SA, Abo Elwafa DA, Hussein SA, Fukano K, Kato T, Shoji I, Chayama K, Muramatsu M, Isogawa M, Wakita T, Merk D, Aly HH. RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking. Antiviral Res. 2025 Aug;240:106214.

8: Makokha GN, Abuduwaili M, Chayama K, Hijikata M. What is the future of Mpox outbreak? Virology. 2025 Jun 27;610:110618.

9: Nakayama N, Nakao M, Uchida Y, Ido A, Takikawa Y, Kakisaka K, Kato N, Chayama K, Inoue K, Kasahara M, Terai S, Ohira H, Sakaida I, Takami T, Hasegawa K, Abe M, Shimizu M, Yoshiji H, Genda T, Inui A, Abe R, Takikawa H, Tanaka A, Mochida S. Nationwide survey of patients with acute liver failure and late-onset hepatic failure in Japan seen between 2016 and 2021. Hepatol Res. 2025 Jun;55(6):932-947.

10: Kajikawa M, Mohamad Yusoff F, Yamaji T, Maruhashi T, Kishimoto S, Harada T, Mizobuchi A, Tanigawa S, Nakano Y, Chayama K, Goto C, Nakashima A, Higashi Y. Effects of low-intensity pulsed ultrasound on clinical parameters in atherosclerotic peripheral artery disease patients with chronic limb-threatening ischemia. Sci Rep. 2025 Apr 1;15(1):11147.

11: Nakatsuka T, Tateishi R, Sato M, Hashizume N, Kamada A, Nakano H, Kabeya Y, Yonezawa S, Irie R, Tsujikawa H, Sumida Y, Yoneda M, Akuta N, Kawaguchi T, Takahashi H, Eguchi Y, Seko Y, Itoh Y, Murakami E, Chayama K, Taniai M, Tokushige K, Okanoue T, Sakamoto M, Fujishiro M, Koike K. Deep learning and digital pathology powers prediction of HCC development in steatotic liver disease. Hepatology. 2025 Mar 1;81(3):976-989.

12: Crouchet E, Dachraoui M, Jühling F, Roehlen N, Oudot MA, Durand SC, Ponsolles C, Gadenne C, Meiss-Heydmann L, Moehlin J, Martin R, Brignon N, Del Zompo F, Teraoka Y, Aikata H, Abe-Chayama H, Chayama K, Saviano A, Heide D, Onea M, Geyer L, Wolf T, Felli E, Pessaux P, Heikenwälder M, Chambon P, Schuster C, Lupberger J, Mukherji A, Baumert TF. Targeting the liver clock improves fibrosis by restoring TGF-β signaling. J Hepatol. 2025 Jan;82(1):120-133.

13: Shi Z, Mhlanga A, Ishida Y, Josephson A, Collier NT, Abe-Chayama H, Tateno-Mukaidani C, Cotler SJ, Ozik J, Major M, Feld JJ, Chayama K, Dahari H. Theoretical modeling of hepatitis C acute infection in liver-humanized mice support pre-clinical assessment of candidate viruses for controlled-human-infection studies. Sci Rep. 2024 Dec 30;14(1):31826.

14: Shekhtman L, Ishida Y, Tsuge M, Reinharz V, Yamao M, Takahashi M, Tateno C, Uprichard SL, Dahari H, Chayama K. Modeling of hepatitis B virus kinetics and accumulation of cccDNA in primary human hepatocytes. JHEP Rep. 2024 Dec 24;7(4):101311.

15: Duehren S, Uchida T, Tsuge M, Hiraga N, Uprichard SL, Etzion O, Glenn J, Koh C, Heller T, Cotler SJ, Oka S, Chayama K, Dahari H. Interferon alpha induces a stronger antiviral effect than interferon lambda in HBV/HDV infected humanized mice. Virus Res. 2024 Nov;349:199451.

16: Crouchet E, Almeida N, Durand SC, Parnot M, Oudot MA, Giannone F, Gadenne C, Roehlen N, Saviano A, Felli E, Pessaux P, Duong HT, Ohdan H, Aikata H, Chayama K, Baumert TF, Schuster C. A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response. JHEP Rep. 2024 Oct 28;7(2):101252.

17: Macdonald JK, Taylor HB, Wang M, Delacourt A, Edge C, Lewin DN, Kubota N, Fujiwara N, Rasha F, Marquez CA, Ono A, Oka S, Chayama K, Lewis S, Taouli B, Schwartz M, Fiel MI, Drake RR, Hoshida Y, Mehta AS, Angel PM. The Spatial Extracellular Proteomic Tumor Microenvironment Distinguishes Molecular Subtypes of Hepatocellular Carcinoma. J Proteome Res. 2024 Sep 6;23(9):3791-3805.

18: Makokha GN, Bao H, Hayes CN, Abuduwaili M, Songok E, Hijikata M, Chayama K. The Prevalence and Genotype Distribution of Hepatitis C Virus in Kenya: A Systematic Review and Meta-Analysis. J Epidemiol Glob Health. 2024 Sep;14(3):677-689.

19: Mukherji A, Jühling F, Simanjuntak Y, Crouchet E, Del Zompo F, Teraoka Y, Haller A, Baltzinger P, Paritala S, Rasha F, Fujiwara N, Gadenne C, Slovic N, Oudot MA, Durand SC, Ponsolles C, Schuster C, Zhuang X, Holmes J, Yeh ML, Abe-Chayama H, Heikenwälder M, Sangiovanni A, Iavarone M, Colombo M, Foung SKH, McKeating JA, Davidson I, Yu ML, Chung RT, Hoshida Y, Chayama K, Lupberger J, Baumert TF. An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection. Nat Commun. 2024 Aug 29;15(1):7486.

20: Qin XY, Shirakami Y, Honda M, Yeh SH, Numata K, Lai YY, Li CL, Wei F, Xu Y, Imai K, Takai K, Chuma M, Komatsu N, Furutani Y, Gailhouste L, Aikata H, Chayama K, Enomoto M, Tateishi R, Kawaguchi K, Yamashita T, Kaneko S, Nagaoka K, Tanaka M, Sasaki Y, Tanaka Y, Baba H, Miura K, Ochi S, Masaki T, Kojima S, Matsuura T, Shimizu M, Chen PJ, Moriwaki H, Suzuki H. Serum MYCN as a predictive biomarker of prognosis and therapeutic response in the prevention of hepatocellular carcinoma recurrence. Int J Cancer. 2024 Aug 1;155(3):582-594.

21: Abe-Chayama H, Kawase T, Ichinohe T, Ishida Y, Tateno C, Hijikata M, Chayama K. Hepatitis B virus-specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate HBV-infected hepatocytes in mice. FEBS Lett. 2024 Jun;598(11):1354-1365.

22: Toyoda H, Tada T, Uojima H, Nozaki A, Chuma M, Takaguchi K, Hiraoka A, Abe H, Itobayashi E, Matsuura K, Atsukawa M, Watanabe T, Shimada N, Nakamuta M, Kojima M, Tsuji K, Mikami S, Ishikawa T, Yasuda S, Tsutsui A, Arai T, Kumada T, Tanaka Y, Tanaka J, Chayama K. Comparison of six hepatocellular carcinoma prediction models in Japanese patients after sustained virologic response undergoing rigorous surveillance for hepatocellular carcinoma. J Gastroenterol Hepatol. 2024 May;39(5):949-954.

23: Toyoda H, Koshiyama Y, Yasuda S, Kumada T, Chayama K, Akita T, Tanaka J. Effect of previous infection with hepatitis B virus on the incidence of hepatocellular carcinoma after sustained virologic response in patients with chronic hepatitis C virus infection. J Viral Hepat. 2024 Mar;31(3):137-142.

24: Yamauchi M, Ono A, Amioka K, Fujii Y, Nakahara H, Teraoka Y, Uchikawa S, Fujino H, Nakahara T, Murakami E, Okamoto W, Miki D, Kawaoka T, Tsuge M, Imamura M, Hayes CN, Ohishi W, Kishi T, Kimura M, Suzuki N, Arihiro K, Aikata H, Chayama K, Oka S. Lenvatinib activates anti-tumor immunity by suppressing immunoinhibitory infiltrates in the tumor microenvironment of advanced hepatocellular carcinoma. Commun Med (Lond). 2023 Oct 25;3(1):152.

25: Uchida T, Imamura M, Hayes CN, Suehiro Y, Teraoka Y, Ohya K, Aikata H, Abe-Chayama H, Ishida Y, Tateno C, Hara Y, Hino K, Okamoto T, Matsuura Y, Aizaki H, Wake K, Kohara M, Liang TJ, Oka S, Chayama K. HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology. 2023 Sep 1;78(3):929-942.

26: Hailegiorgis A, Ishida Y, Collier N, Imamura M, Shi Z, Reinharz V, Tsuge M, Barash D, Hiraga N, Yokomichi H, Tateno C, Ozik J, Uprichard SL, Chayama K, Dahari H. Modeling suggests that virion production cycles within individual cells is key to understanding acute hepatitis B virus infection kinetics. PLoS Comput Biol. 2023 Aug 3;19(8):e1011309.

27: Uchida T, Teraoka Y, Imamura M, Abe-Chayama H, Makokha GN, Hayes CN, Aikata H, Hamamura S, Ishida Y, Tateno C, Shirouzu T, Kawai S, Tanaka Y, Ohdan H, Okada S, Chayama K. A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system. J Viral Hepat. 2023 Mar;30(3):262-272.

28: Yoshikawa Y, Imamura M, Yamauchi M, Hayes CN, Aikata H, Okamoto W, Miyata Y, Okada M, Hattori N, Sugiyama K, Yoshioka Y, Toratani S, Takechi M, Ichinohe T, Ueda T, Takeno S, Kobayashi T, Ohdan H, Teishima J, Hide M, Nagata Y, Kudo Y, Iida K, Chayama K. Prevalence of immune-related adverse events and anti-tumor efficacy following immune checkpoint inhibitor therapy in Japanese patients with various solid tumors. BMC Cancer. 2022 Nov 29;22(1):1232.